Method for flow measurement in microfluidic channels based on electrical impedance spectroscopy

Microfluidic flow transducer based on the measurement of electrical admittance.

A new flow transducer for measuring the flow rate of a conducting fluid in a microchannel is reported. In this paper, the measure of flow of such fluid under laminar flow conditions based on the change of electrical admittance is established with the aid of a pair of electrodes parallel to the line of flow in a glass-PDMS microfluidic device. This flow sensor is simple in design and can be inte...

Microfluidic biosensor for single cell high speed flow impedance spectroscopy

This paper presents a micro-biosensor based on Electrical Bio-Impedance Spectroscopy (EBIS), applied to blood cells characterization and diagnosis. This sensor uses microfluidic flow, coupled to EBIS system to perform cell by cell measurements at high flow rate, up to several hundred cells per second. Two devices were realized with different materials, SU_8 resin and polydimethylsyloxane PDMS t...

Integrated optical measurement system for fluorescence spectroscopy in microfluidic channels

An Electrical Model Optimization for Single Cell Flow Impedance Spectroscopy

This paper presents an optimization of a single cell electrical model, based on Maxwell’s mixture Theory, applied to flow cytometry coupled to impedance spectroscopy. It is based on the discretization of the measurement area into a square reference volume, centered between microelectrodes, and fixed impedance areas. The first one represents the sensing area, the one impacted by cell presence du...

Microfluidic Platelet Analysis Platform Based on Impedance Spectroscopy

We present a microfluidic platform for platelet analysis based on multi-frequency electrical impedance spectroscopy (EIS). Two-phase dielectric focusing is used to enable sensitive detection while maintaining low shear forces to avoid platelet activation. Discrimination between erythrocytes and platelets was achieved by measuring the in-phase amplitude at a single frequency. Discrimination betw...